Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions.
Lactate has long been considered a "waste" by-product of cell metabolism, and it accumulates at sites of inflammation.Recent findings have identified lactate as an active metabolite in cell signalling, although its effects on immune cells during inflammation are largely unexplored.Here we ask whether lactate is responsible for T cells remaining ent